It is important to have reliable information on various natural and anthropogenic factors responsible for influencing and shaping stream water quality parameters as long as water resource conservation and management planning are concerned from the local to global scale. Daunting environmental pressures at multiple scales makes this necessity more pronounced owing to the special role of stream ecosystems in providing regional services. Understanding how coupled effect of natural and anthropogenic factors controls stream water quality parameters and how the relationships change over space and time will help policy makers and resource managers to target appropriate scales at watershed level for the quality management of stream waters. This paper sums up the information on various natural and anthropocentric factors as major determinants responsible for conditioning and shaping stream water quality parameters and their simultaneous influence on biota and its use.