Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin

Published on Nov 1, 2020in Polymer Bulletin2.014
· DOI :10.1007/S00289-019-03027-Z
Sara Nadem1
Estimated H-index: 1
(IAU: Islamic Azad University),
Hakimeh Ziyadi4
Estimated H-index: 4
(IAU: Islamic Azad University)
+ 1 AuthorsMitra Baghali2
Estimated H-index: 2
(IAU: Islamic Azad University)
Given the importance of nanofibers in the field of pharmaceutical sciences and drug delivery applications, this study aimed to use poly(vinyl alcohol) (PVA) nanofibers as drug carriers for clindamycin. First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of reference carrier. Then, 8% PVA solution containing 2% clindamycin was electrospun under optimum conditions at 20 kV voltage, 10 cm for nozzle-to-collector distance and an injection rate of 1 mL/h. In order to control drug release and improve the surface wet ability, the prepared polymeric nanofibers were cross-linked by glutaraldehyde. The prepared mats of nanofibers were characterized using scanning electron microscopy, atomic force microscopy, Fourier transform infrared and contact angle analysis. The in vitro drug release from nanofibers into the phosphate-buffered saline solution was measured by high-performance liquid chromatography at a wavelength of 210 nm. The in vitro drug release showed that cross-linked nanofibers had a lower drug release rate in a longer time.
📖 Papers frequently viewed together
2 Citations
33 Citations
#1Zafar Khan Ghouri (Texas A&M University at Qatar)H-Index: 17
#2Khaled Elsaid (Texas A&M University at Qatar)H-Index: 17
Last. Mohammed Shaheer Akhtar (CBNU: Chonbuk National University)H-Index: 1
view all 5 authors...
4 CitationsSource
#1Zafar Khan Ghouri (Qatar University)H-Index: 17
#2Khaled Elsaid (Texas A&M University at Qatar)H-Index: 17
Last. Nasser A.M. Barakat (CBNU: Chonbuk National University)H-Index: 53
view all 4 authors...
Besides the high-current density, lower onset potential of urea electrooxidation is key parameter which influences the direct urea fuel cell performance. In the present article, low-onset potential has been reported for nickel-free (NF) electrocatalyst in urea electrooxidation. The nickel-free electrocatalyst: Co3O4–SrCO3 heterostructure nanorods-incorporated carbon nanofibers (CNFs) were synthesized by electrospinning technique, followed by calcination of electrospun mat composed of strontium a...
17 CitationsSource
#1Rramaswamy Ravikumar (Hanseo University)H-Index: 5
#2Mani Ganesh (Hanseo University)H-Index: 15
Last. Hyun Tae Jang (Hanseo University)H-Index: 19
view all 5 authors...
Abstract Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its in vitro CUR diffusion properties. Various CAP solutions from 5 to 20 wt% were tested; 17.5 wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using sc...
25 CitationsSource
#1Mina bagherian farH-Index: 1
#2Hakimeh Ziyadi (IAU: Islamic Azad University)H-Index: 4
Last. Hakimeh ZiyadiH-Index: 1
view all 2 authors...
The Poly (vinyl alcohol)/Kefirane nanofiber membrane was successfully fabricated for the firsttime using electrospinning of the polyvinyl alcohol (PVA) and Kefirane blend solution. Scanningelectron microscope (SEM), attenuated total reflectance Fourier transform infrared (ATRFT-IR), and differential scanning calorimetry (DSC) were used to characterize the electrospunPoly (vinyl alcohol)/Kefirane fiber membranes. Similar analysis was done for polyvinyl alcoholnanofibers. Then, the results were co...
5 Citations
#1Shih-Feng Chou (UW: University of Washington)H-Index: 11
#2Daniel Carson (UW: University of Washington)H-Index: 4
Last. Kim A. Woodrow (UW: University of Washington)H-Index: 19
view all 3 authors...
Abstract Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desir...
248 CitationsSource
#1István Sebe (Semmelweis University)H-Index: 7
#2Peter Szabo (Semmelweis University)H-Index: 36
Last. Romána Zelkó (Semmelweis University)H-Index: 20
view all 4 authors...
Abstract Over the past several decades, the formulation of novel nanofiber-based drug delivery systems focusing on specific delivery purposes has been investigated worldwide with a continuous level of interest. The unique structure and properties of nanoscale fibrous systems, such as their high specific-area-to-volume ratio and high porosity and the possibility of controlling their crystalline–amorphous phase transitions, make them a desirable formulation pathway to satisfy the needs of recent p...
77 CitationsSource
#1Iván E. Moreno-Cortez (Universidad Autónoma de Nuevo León)H-Index: 8
Last. Rodolfo Cruz-Silva (Shinshu University)H-Index: 29
view all 6 authors...
Abstract In this paper, papain enzyme (E.C., 1.6 U/mg) was successfully immobilized in poly(vinyl alcohol) (PVA) nanofibers prepared by electrospinning. The morphology of the electrospun nanofibers was characterized by scanning electron microscopy (SEM) and the diameter distribution was in the range of 80 to 170 nm. The presence of the enzyme within the PVA nanofibers was confirmed by infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and energy dispersive X-ray spectr...
56 CitationsSource
#1Zafar Khan Ghouri (CBNU: Chonbuk National University)H-Index: 17
#2Nasser A.M. Barakat (CBNU: Chonbuk National University)H-Index: 53
Last. Hak Yong Kim (CBNU: Chonbuk National University)H-Index: 83
view all 5 authors...
In this study, Co/CeO2 decorated carbon nanofibers are introduced as effective electro-catalyst for methanol oxidation. Poly(vinyl alcohol) was used as carbon source due to its high carbon content characteristic as compared to many others polymer precursors for CNFs synthesis. Preparation of the introduced nanofibers could be achieved by calcination of electrospun nanofibers composed of cerium (III) acetate hydrate, cobalt (II) acetate tetra hydrate and poly(vinyl alcohol) in nitrogen environmen...
54 CitationsSource
#1Priya Patel (Saurashtra University)H-Index: 3
#1Priya Patel (Saurashtra University)H-Index: 3
Last. Paresh U PatelH-Index: 6
view all 2 authors...
Objective: The vagina has been studied as a favorable site for the local and systemic delivery of drugs, for female associated conditions. Vaginal preparations, although generally perceived as safer most still associated with number of problems including multiple days of dosing, dripping, leakage and messiness, causing discomfort to users and expulsion due to the self-cleansing action of the vaginal tract. These limitations lead to poor patient compliance and failure of the desired therapeutic e...
30 CitationsSource
#1Elbadawy A. KamounH-Index: 11
#2Xin Chen (Fudan University)H-Index: 59
Last. El-Refaie KenawyH-Index: 24
view all 4 authors...
Abstract A series of excellent poly(vinyl alcohol) (PVA)/polymers blend hydrogel were reviewed using different crosslinking types to obtain proper polymeric dressing materials, which have satisfied biocompatibility and sufficient mechanical properties. The importance of biodegradable–biocompatible synthetic polymers such as PVA, natural polymers such as alginate, starch, and chitosan or their derivatives has grown significantly over the last two decades due to their renewable and desirable biolo...
303 CitationsSource
Cited By5
#1Sibusiso Alven (University of Fort Hare)H-Index: 3
#2Vuyolwethu Khwaza (University of Fort Hare)H-Index: 2
Last. Blessing Atim Aderibigbe (University of Fort Hare)H-Index: 16
view all 4 authors...
The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound managem...
#1Sibusiso Alven (University of Fort Hare)H-Index: 3
#2Blessing Atim Aderibigbe (University of Fort Hare)H-Index: 16
The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (e-caprolactone) display interesting properties, including good...
1 CitationsSource
#1P. Yousefi (UI: University of Isfahan)
#2Ghasem Dini (UI: University of Isfahan)H-Index: 12
Last. Mehdi Mehdikhani (UI: University of Isfahan)H-Index: 5
view all 5 authors...
In this study, for the first time, core/shell nanofibrous mats of polycaprolactone (PCL) and chitosan (CS) as a carrier for the rosuvastatin (RSV) drug were fabricated. To do this, the electrospinning technique using a two-fluid stainless steel coaxial spinneret consisted of two concentrically arranged needles was used. The CS layer as a shell contained 5% (w/w) of the RSV drug. The fabricated nanofibrous mats were characterized by different techniques, including scanning electron microscopy (SE...
1 CitationsSource
#1Ying Tang (BTBU: Beijing Technology and Business University)H-Index: 2
#2Lei Liu (BTBU: Beijing Technology and Business University)H-Index: 2
Last. Hua Zhao (BTBU: Beijing Technology and Business University)
view all 8 authors...
Herbal extracts have recently received considerable interest in acne therapy owing to their enhanced skin compatibility compared with antibiotics and synthetic agents. In this study, electrospun poly (vinyl alcohol)/chitosan (PVA/CS) fibrous patch incorporating a combination of herbal extracts with complementary mechanisms of action was developed as an alternative acne therapy for patients with resistance to the conventional treatments. The herbal extracts-loaded electrospun fibers displayed uni...
1 CitationsSource
#1Fatemeh Mehrali (IAU: Islamic Azad University)H-Index: 1
#2Hakimeh Ziyadi (IAU: Islamic Azad University)H-Index: 4
Last. Mahnaz Qomi (IAU: Islamic Azad University)H-Index: 9
view all 5 authors...
The kefiran/polyvinyl alcohol and polyvinyl pyrrolidone nanofibers were effectively fabricated for the first time using electrospinning of poly(vinyl alcohol), poly(vinyl pyrrolidone) and kefiran blend solution. The effect of solution parameters, such as kefiran concentration and poly(vinyl alcohol)/poly(vinyl pyrrolidone) mixing ratio, were considered. The parameters’ effects, such as voltage, nozzle-to-collector distance and feeding rate on nanofibers morphology, were also checked by the scann...
2 CitationsSource