Qixianqingming granules (QXQM) comprise a traditional Chinese medicine (TCM) formula that was developed based on the combination of TCM theory and clinical practice. This formula has been proven to effectively treat asthma. In this study, an analytical procedure using ultraperformance liquid chromatography, coupled with electrospray ionization quadrupole time-of-flight mass spectrometry, was established for the rapid separation and sensitive identification of the chemical components in QXQM and its metabolites in serum of rats. Seventy-two compounds were systematically identified in QXQM, including flavonoids, terpenoids, anthraquinones, phenylethanoid glycosides, stilbenes, alkaloids, and organic acids. Thirteen prototype compounds and 29 metabolites were detected in the serum of rats. The results provided fundamental information for further studying the mechanisms and clinical application of QXQM.
#1Jinfeng Fu(MOE: Chinese Ministry of Education)H-Index: 4
#2Songyan Wu(MOE: Chinese Ministry of Education)H-Index: 1
Last. Rui Song(CPU: China Pharmaceutical University)H-Index: 15
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: Rhizoma et Radix Polygoni Cuspidati (RRPC) is commonly prescribed for the treatment of amenorrhea, arthralgia, jaundice and abscess in traditional Chinese medicine. Previous pharmacological studies have indicated that polyphenols are the main pharmacological active ingredients in RRPC. Meanwhile, the poor bioavailability of polyphenols in RRPC implies that those components are probably metabolized by intestinal bacteria before absorption. However, there is rather limited information about RRPC...
Abstract The separation, identification and quantification of constituents in complex plant extracts always has been, and most likely will be, a challenging task. Nevertheless, today a multiplicity of different separation techniques, specific stationary phases and detectors are available, helping to achieve the desired selectivity, sensitivity and speed for nearly any separation problem. The most prominent and popular technique in this area of research is definitely the combination of liquid chr...
ShenKang injection is traditional Chinese medicine used to treat chronic renal failure in China. It is a compound preparation that consists of four herbs: Rhubarb, Salvia miltiorrhiza, Safflower and Radix Astragali. We developed an ultra high pressure liquid chromatography coupled with Q Exactive hybrid quadrupole-orbitrap high resolution accurate mass spectrometry tandem mass spectrometry method to analyze its chemical compositions, and a total of 90 compounds were identified from ShenKang inje...
Abstract The iridoid profile of four Vaccinium species was investigated using UHPLC-MS to obtain further information about this group of species for phytochemical characterization. Fruits of bog bilberry (Vaccinium uliginosum L.) showed 14 different iridoid glycosides with a total amount of 20 mg/kg fresh weight (FW), whereas bilberry (Vaccinium myrtillus L.) contained 11 iridoid glycosides and a total amount of 127 mg/kg FW. Highbush blueberry (Vaccinium corymbosum L.) and lowbush blueberry (Va...
Last. Yi Feng(SHU: Shanghai University)H-Index: 22
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Abstract Ethnopharmacological relevance Chinese herbs have been used in China for thousands of years and are also becoming popular in Western medicine. Formulae of traditional Chinese medicine (TCM), which contain two or more herbs, can often obtain better curative efficacies and fewer side effects than single herbs. Though there are many reports on pharmaceutics, pharmacokinetics, and pharmacodynamics of TCM, there remains a serious lack of summarization and systemic analyses of these reported ...
Abstract Traditional Chinese medicine (TCM) has more than 2,000 years of history and has gained widespread clinical applications. However, the explicit role of TCM in preventing and treating cardiovascular disease remains unclear due to a lack of sound scientific evidence. Currently available randomized controlled trials on TCM are flawed, with small sample sizes and diverse outcomes, making it difficult to draw definite conclusions about the actual benefits and harms of TCM. Here, we systematic...
Last. Xian Li(ZJU: Zhejiang University)H-Index: 38
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Loquat (Eriobotrya japonica Lindl.) is a subtropical fruit tree with high medicinal value native to China. Different organs of loquat have been used historically as folk medicines and this has been recorded in Chinese history for thousands of years. Research shows that loquat extracts contain many antioxidants, and different extracts exhibit bioactivity capable of counteracting inflammation, diabetes, cancer, bacterial infection, aging, pain, allergy and other health issues. Bioactive compounds ...
Last. Wei Xiao(Nanjing University of Chinese Medicine)H-Index: 5
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To analyze and identify the chemical constituents from Yinyanghuo Zonghuangtong capsule by using UPLC/Q-TOF-MS/MS. Chromatographic separation was carried out on an Agilent SB-C₁₈ column (2.1 mm×100 mm, 1.8 μm) at the temperature of 30 ℃. The mobile phase was 0.1% formic acid and acetonitrile by gradient elution, with a flow rate at 0.30 mL•min⁻¹, and the injection volume of 2 μL. The MS spectrum was acquired in both negative and positive ion modes using ESI ion source. Based on relative accurate...
Last. Junli Hong(Nanjing Medical University)H-Index: 14
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In this work, magnetic molecularly imprinted polymers (MMIPs) were successfully prepared for specific recognition and selective enrichment of metabolite groups of Polygonum cuspidatum extract in rat plasma. Two kinds of MMIPs were obtained using polydatin (PD) and emodin-8-O-β-D-glucoside (EG) as template molecules, respectively, methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linker and 2,2′-azobisisobutyronitrile as initiator. The membrane thickness of both MMIP...
Last. Haibin Qu(ZJU: Zhejiang University)H-Index: 30
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Abstract Fufang Ejiao Syrup (FES) is a widely used immune-boosting Traditional Chinese Medicine (TCM) in Eastern Asian countries. This study attempts to investigate the bioactive compounds in FES. First, FES extract was separated into fractions to facilitate the investigation and 72 compounds were identified using LC–MSn. Subsequently, Immune-enhancement effects of FES and its components were investigated on bone marrow cells and neuroprotective effects against H2O2 induced oxidative damage were...