Multifunctional Nanoscale Metal–Organic Layers for Ratiometric pH and Oxygen Sensing

As a monolayered version of nanoscale metal–organic frameworks (nMOFs), nanoscale metal–organic layers (nMOLs) represent an emerging class of highly tunable two-dimensional materials for hierarchical functionalization and with facile access to analytes. Here we report the design of the first nMOL-based biosensor for ratiometric pH and oxygen sensing in mitochondria. Cationic Hf12-Ru nMOL was solvothermally synthesized by laterally connecting...