Phenol

Supramolecular chemistry

Engineering

Materials science

Pillar

Formaldehyde

Biochemistry

Molecule

Chemical engineering

Porosity

Physical chemistry

Nanotechnology

Organic chemistry

Solid-state

Macromolecule

Porous medium

Structural engineering

Chemistry

Host–guest chemistry

Cyclohexane

Benzene

Angewandte Chemie International Edition

Tiara[5]arenes (T[5]s), a new class of five-fold symmetric oligophenolic macrocycles that are not accessible from the addition of formaldehyde to phenol, were synthesized for the first time. These pillar[5]arene-derived structures display both unique conformational freedom, differing from that of pillararenes, with a rich blend of solid-state conformations and excellent host-guest interactions in solution. Finally we show how this novel macrocyclic scaffold can be functionalized in a variety of ways and used as functional crystalline materials to distinguish uniquely between benzene and cyclohexane.

Tiara[5]arenes: Synthesis, Solid‐State Conformational Studies, Host–Guest Properties, and Application as Nonporous Adaptive Crystals