Review paper

The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease

Volume: 21
Published: Jan 1, 2019
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease and is caused by heterozygous germ-line mutations in either PKD1 (85%) or PKD2 (15%). It is characterised by the formation of numerous fluid-filled renal cysts and leads to adult-onset kidney failure in ~50% of patients by 60 years. Kidney cysts in ADPKD are focal and sporadic, arising from the clonal proliferation of collecting-duct principal cells,...
Paper Details
Title
The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease
Published Date
Jan 1, 2019
Volume
21
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