Green preparation of pH-responsive and dual targeting hyaluronic acid nanogels for efficient protein delivery

PEGylated protein delivery systems that effectively improve the efficiency of protein delivery often suffer limitations of uncontrollable release and non-targeting. In this study, pH-responsive nanogels are developed by forming benzoic imine bonds between hyaluronic acid-graft-methoxy poly(ethylene glycol)-diethylenetriamine (HA-PEG-Diet) copolymers and terephthalaldehyde (TPA) crosslinkers for dual-targeting protein delivery. Cytochrome C (CC),...