TIP60/KAT5 is required for neuronal viability in hippocampal CA1
Abstract
Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency in the adult forebrain leads within days to extensive transcriptional dysfunction characterized by the presence of a neurodegeneration-related signature in CA1. Cell cycle- and immunity-related genes...
Paper Details
Title
TIP60/KAT5 is required for neuronal viability in hippocampal CA1
Published Date
Nov 7, 2019
Journal
Volume
9
Issue
1
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