Acinetobacter

Population

Antibiotics

Bacteria

Escherichia coli

Biology

Microbiology

Gene

Gram-negative bacteria

Acinetobacter baumannii

Stenotrophomonas maltophilia

Carbapenem

Stenotrophomonas

Carbapenem-resistant enterobacteriaceae

Pseudomonas aeruginosa

Pseudomonas

Enterobacteriaceae

Genetics

Biochemistry

Medicine

Antibiotic resistance

Environmental health

Clinical Infectious Diseases

Carbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of carbapenem resistance requires the consideration of both carbapenemase-producing bacteria as well as bacteria with other carbapenem resistance mechanisms. Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbapenem-resistant organisms can help us gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics.

Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria