Drug resistance

Biotechnology

Leishmaniasis

Resistance (ecology)

Biology

Microbiology

World Wide Web

Virology

Ecology

In vitro

Immunology

Malaria

Plasmodium falciparum

Antiprotozoal

Trypanosoma

Leishmania

Drug

Computer science

Parasite hosting

Biochemistry

Medicine

Pharmacology

International Journal of Molecular Sciences

Protozoan diseases continue to be a worldwide social and economic health problem. Increased drug resistance, emerging cross resistance, and lack of new drugs with novel mechanisms of action significantly reduce the effectiveness of current antiprotozoal therapies. While drug resistance associated to anti-infective agents is a reality, society seems to remain unaware of its proportions and consequences. Parasites usually develops ingenious and innovative mechanisms to achieve drug resistance, which requires more research and investment to fight it. In this review, drug resistance developed by protozoan parasites Plasmodium, Leishmania, and Trypanosoma will be discussed.

An Overview of Drug Resistance in Protozoal Diseases