Radiation treatment planning

Radiation

Proton

Biological effect

Surgery

Nuclear physics

Medical physics

Scaling

Radiation therapy

Radiology

Relative biological effectiveness

Photon

Physics

Mathematics

Optics

Internal medicine

Geometry

Medicine

Proton therapy

Nuclear medicine

British Journal of Radiology

Dose in proton radiotherapy is generally prescribed by scaling the physical proton dose by a constant value of 1.1. Relative biological effectiveness (RBE) is defined as the ratio of doses required by two radiation modalities to cause the same level of biological effect. The adoption of an RBE of 1.1. assumes that the biological efficacy of protons is similar to photons, allowing decades of clinical dose prescriptions from photon treatments and protocols to be utilized in proton therapy. There is, however, emerging experimental evidence that indicates that proton RBE varies based on technical, tissue and patient factors. The notion that a single scaling factor may be used to equate the effects of photons and protons across all biological endpoints and doses is too simplistic and raises concern for treatment planning decisions. Here, we review the models that have been developed to better predict RBE variations in tissue based on experimental data as well as using a mechanistic approach.

Modelling variable proton relative biological effectiveness for treatment planning