Radium-223 mechanism of action: implications for use in treatment combinations
Abstract
The targeted alpha therapy radium-223 (223Ra) can prolong survival in men with castration-resistant prostate cancer (CRPC) who have symptomatic bone metastases and no known visceral metastases. Preclinical studies demonstrate that 223Ra preferentially incorporates into newly formed bone matrix within osteoblastic metastatic lesions. The emitted high-energy alpha particles induce DNA double-strand breaks that might be irreparable and lead to cell...
Paper Details
Title
Radium-223 mechanism of action: implications for use in treatment combinations
Published Date
Nov 11, 2019
Journal
Volume
16
Issue
12
Pages
745 - 756
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