Review paper
Antibody–Drug Conjugates: A Comprehensive Review
Abstract
Antibody-drug conjugates (ADC) are one of the fastest growing anticancer drugs. This approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that directed toward a target antigen expressed on the cancer cell surface, reducing systemic exposure and therefore toxicity. ADCs are complex molecules that require careful attention to various components. Selection of an appropriate target, an mAb, cytotoxic payload, and the...
Paper Details
Title
Antibody–Drug Conjugates: A Comprehensive Review
Published Date
Jan 1, 2020
Journal
Volume
18
Issue
1
Pages
3 - 19
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Notes
History