Synthetic and biological approaches to map substrate specificities of proteases
Abstract
Proteases are regulators of diverse biological pathways including protein catabolism, antigen processing and inflammation, as well as various disease conditions, such as malignant metastasis, viral infection and parasite invasion. The identification of substrates of a given protease is essential to understand its function and this information can also aid in the design of specific inhibitors and active site probes. However, the diversity of...
Paper Details
Title
Synthetic and biological approaches to map substrate specificities of proteases
Published Date
Oct 22, 2019
Journal
Volume
401
Issue
1
Pages
165 - 182
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