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Original paper

Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation

Volume: 141, Issue: 45, Pages: 18230 - 18237
Published: Oct 21, 2019
Abstract
Histidine (His) carries a unique heteroaromatic imidazole side chain and plays irreplaceable functional roles in peptides and proteins. Existing strategies for site-selective histidine modification predominantly rely on the N-substitution reactions of the moderately nucleophilic imidazole group, which inherently suffers from the interferences from lysine and cysteine residues. Chemoselective modification of histidine remains one of the most...
Paper Details
Title
Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation
Published Date
Oct 21, 2019
Volume
141
Issue
45
Pages
18230 - 18237
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