P2256Aging and inhibition of Nox4 and Nox1 exacerbate perivascular inflammation in spontaneous hypertension

Introduction Hypertension is associated with enhanced NADPH oxidase activation and increased accumulation of immune cells leading to perivascular inflammation. However, while aging and oxidative stress are a major factor for the development of hypertension, their effect on perivascular inflammation remains unclear. Purpose We aimed to establish the interaction between aging, oxidative stress and perivascular inflammation. We hypothesize that the...