A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies
Abstract
As a versatile therapeutic modality, peptides attract much attention because of their great binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein surfaces. However, the deficiency of cell permeability and metabolic stability always limits the success of in vitro bioactive peptides as drug candidates. Peptide macrocyclization is one of the most established strategies to overcome these limitations....
Paper Details
Title
A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies
Published Date
Oct 9, 2019
Journal
Volume
40
Issue
2
Pages
753 - 810
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