International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Abstract
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses...
Paper Details
Title
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Published Date
Oct 8, 2019
Journal
Volume
10
Issue
1
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