Virology

Interferon

Immune system

Virus

Biology

Gene

Cell biology

RNA interference

MDA5

Innate immune system

Hepatitis C virus

Genetics

Cell Host & Microbe

14-3-3 protein family members facilitate the translocation of RIG-I-like receptors to signaling organelles. Riedl et al. show that the NS3 protein of Zika virus physically interacts with the scaffolding proteins 14-3-3ϵ and 14-3-3η to block cytosol-to-mitochondria translocation of the sensors RIG-I and MDA5 and thereby evade antiviral innate immune responses.

Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity