Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
Abstract
Activation of cell surface receptor integrin has been extensively studied as the first key step to trigger cell adhesion, but the subsequent events, widely regarded as integrin "outside-in" signaling to form supramolecular complexes (focal adhesions [FAs]) to promote dynamic cell adhesion, remain poorly elucidated. Integrin activator kindlin-2 was recently found to associate with paxillin in nascent FAs, implicating an early yet undefined...
Paper Details
Title
Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
Published Date
Nov 1, 2019
Journal
Volume
27
Issue
11
Pages
1686 - 1697.e5
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