Internal medicine

Coronary artery disease

Population

Myocardial infarction

Biology

Gastroenterology

Gene

Genotype

Cardiology

Allele

Single-nucleotide polymorphism

Haplotype

Cholesterol

Cholesterol 7 alpha-hydroxylase

Genetics

Medicine

Environmental health

Biomarkers in Medicine

Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. Method: We studied haplotype-tagging single nucleotide polymorphisms of CYP7A1 in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. Results: We did not find the genetic variants of CYP7A1 to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is associated with modified concentrations of serum total cholesterol and LDL. We also found that the C allele and the CC genotype of the rs11786580 are more frequent in patients with myocardial infarction. This association was especially strong after the group differentiation by sex.

The Relationship Between <i>CYP7A1</i> Polymorphisms, Coronary Artery Disease &amp; Serum Lipid Markers

The Relationship Between CYP7A1 Polymorphisms, Coronary Artery Disease & Serum Lipid Markers