Original paper
Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates
Abstract
Bloom helicase (BLM) and its orthologs are essential for the maintenance of genome integrity. BLM defects represent the underlying cause of Bloom Syndrome, a rare genetic disorder that is marked by strong cancer predisposition. BLM deficient cells accumulate extensive chromosomal aberrations stemming from dysfunctions in homologous recombination (HR). BLM participates in several HR stages and helps dismantle potentially harmful HR intermediates....
Paper Details
Title
Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates
Published Date
Sep 18, 2019
Journal
Volume
47
Issue
21
Pages
11225 - 11237