Internal medicine

Notch signaling pathway

Tumor microenvironment

Colorectal cancer

Biology

Cancer

Metastasis

Signal transduction

Cell biology

Tumor cells

Cancer research

Medicine

Cancer Cell

The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastasis; with >80% liver metastases) in Kras

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis