Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

eLife7.70
Volume: 8
Published: Sep 23, 2019
Abstract
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two environments have not been considered separately, MuSC behaviors in overloaded muscle remain unexamined. Here, we show that most MuSCs in overloaded muscle, unlike MuSCs in regenerating muscle, proliferate in the absence of MyoD expression. Mechanistically, MuSCs in overloaded muscle sustain the...
Paper Details
Title
Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle
Published Date
Sep 23, 2019
Journal
Volume
8
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