Angiotensin Receptor Neprilysin Inhibitor for Patients With Heart Failure and Reduced Ejection Fraction: Real-World Experience From Taiwan.

Published on Mar 1, 2020in Journal of Cardiovascular Pharmacology and Therapeutics2.322
· DOI :10.1177/1074248419872958
Fu-Chih Hsiao4
Estimated H-index: 4
(CGU: Chang Gung University),
Chun-Li Wang14
Estimated H-index: 14
(CGU: Chang Gung University)
+ 3 AuthorsPao-Hsien Chu20
Estimated H-index: 20
(CGU: Chang Gung University)
Background:Angiotensin receptor neprilysin inhibitor (ARNI) was recommended by major guidelines as the frontline therapy for heart failure with reduced ejection fraction (HFrEF) since its clinical ...
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Background null Treatment of heart failure with reduced ejection fraction (HFrEF) has been revolutionized by angiotensin receptor/neprilysin inhibitor (ARNI). ARNI has been shown to significantly reduce morbidity and mortality in a large, randomized controlled trial. However, real-world evaluation of ARNI with a diverse population is still limited. null Methods null HFrEF patients receiving angiotensin receptor/neprilysin inhibitor (ARNI) or standard HF treatment at a university hospital in Thai...
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The Prospective comparison of ARNI with angiotensin-converting enzyme inhibitor to Determine Impact on Global Mortality and morbidity in Heart Failure trial identified a marked reduction in the risk of death and hospitalization for heart failure in patients with heart failure with reduced ejection fraction (HFrEF) treated with sacubitril-valsartan (trade name Entresto), but the physiological processes underpinning these improvements are unclear. We tested the hypothesis that treatment with sacub...
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