Developmental biology

RUNX2

Carcinogenesis

Transcription factor

Biology

Gene

Embryonic stem cell

RUNX1

Stem cell

Computational biology

Cell biology

Genetics

Development

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.

RUNX transcription factors: orchestrators of development