Internal medicine

Pathology

Adenoid cystic carcinoma

Oncology

Malignancy

Carcinoma

Cancer research

Medicine

Journal of Clinical Investigation

BACKGROUND. Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies. To improve outcomes, deeper understanding of genetic alterations and vulnerabilities in R/M tumors is needed.

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma