Gene

Heritability

Sexual behavior

Biology

Social psychology

Developmental psychology

Computer science

Twin study

Evolutionary biology

Single-nucleotide polymorphism

Genetics

Sexual orientation

Inheritance (genetic algorithm)

Psychology

Genome-wide association study

Genetic association

Genotype

Multifactorial Inheritance

Artificial intelligence

Genetic architecture

Quantitative trait locus

Perspective (graphical)

Science

The genetics of sexual orientation Twin studies and other analyses of inheritance of sexual orientation in humans has indicated that same-sex sexual behavior has a genetic component. Previous searches for the specific genes involved have been underpowered and thus unable to detect genetic signals. Ganna et al. perform a genome-wide association study on 493,001 participants from the United States, the United Kingdom, and Sweden to study genes associated with sexual orientation (see the Perspective by Mills). They find multiple loci implicated in same-sex sexual behavior indicating that, like other behavioral traits, nonheterosexual behavior is polygenic. Science , this issue p. eaat7693 ; see also p. 869

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior