Review paper
The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma
Abstract
The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that initial MMP inhibitor clinical trials were held prematurely. Further complicating matters were problematic conclusions drawn from...
Paper Details
Title
The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma
Published Date
Aug 27, 2019
Journal
Volume
8
Issue
9
Pages
984 - 984
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Notes
History