Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER

Volume: 76, Issue: 1, Pages: 191 - 205.e10
Published: Oct 1, 2019
Abstract
Normal mitochondrial functions rely on optimized composition of their resident proteins, and proteins mistargeted to mitochondria need to be efficiently removed. Msp1, an AAA-ATPase in the mitochondrial outer membrane (OM), facilitates degradation of tail-anchored (TA) proteins mistargeted to the OM, yet how Msp1 cooperates with other factors to conduct this process was unclear. Here, we show that Msp1 recognizes substrate TA proteins and...
Paper Details
Title
Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER
Published Date
Oct 1, 2019
Volume
76
Issue
1
Pages
191 - 205.e10
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