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Original paper

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Science44.70
Volume: 365, Issue: 6455, Pages: 786 - 793
Published: Aug 8, 2019
Abstract
Manifold destiny Mapping of genetic interactions (GIs) is usually based on cell fitness as the phenotypic readout, which obscures the mechanistic origin of interactions. Norman et al. developed a framework for mapping and understanding GIs. This approach leverages high-dimensional single-cell RNA sequencing data gathered from CRISPR-mediated, pooled perturbation screens. Diverse transcriptomic phenotypes construct a “manifold” representing all...
Paper Details
Title
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
Published Date
Aug 8, 2019
Journal
Volume
365
Issue
6455
Pages
786 - 793
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