Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development

Volume: 62, Pages: 31 - 47
Published: May 1, 2020
Abstract
The tumor matrix together with inflammation and autophagy are crucial regulators of cancer development. Embedded in the tumor stroma are numerous proteoglycans which, in their soluble form, act as danger-associated molecular patterns (DAMPs). By interacting with innate immune receptors, the Toll-like receptors (TLRs), DAMPs autonomously trigger aseptic inflammation and can regulate autophagy. Biglycan, a known danger proteoglycan, can regulate...
Paper Details
Title
Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development
Published Date
May 1, 2020
Volume
62
Pages
31 - 47
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