Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses

Volume: 129, Issue: 11, Pages: 4922 - 4936
Published: Oct 14, 2019
Abstract
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-maintenance and foster tissue repair. Herein, we investigated whether heart-specific T cells exert salutary or detrimental effects in the context of myocardial infarction (MI), the leading cause of death worldwide. After screening more than 150 class-II-restricted epitopes, we found that myosin heavy chain alpha (MYHCA) was a dominant cardiac antigen triggering...
Paper Details
Title
Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses
Published Date
Oct 14, 2019
Volume
129
Issue
11
Pages
4922 - 4936
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