Longevity

Senescence

Physics

Model organism

Biological pathway

Gene expression

Signal transduction

Gene

Optics

Cell biology

Evolutionary biology

Biology

Mitochondrion

Life span

Genetics

Nutrient sensing

Computational biology

Crosstalk

Ageing Research Reviews

Genetic and pharmacological intervention studies have identified evolutionarily conserved and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing, and genome damage response signaling pathways, as prominent regulators of longevity and health span in various species. Mitochondria are the primary sites of ATP production and are key players in several other important cellular processes. Mitochondrial dysfunction diminishes tissue and organ functional performance and is a commonly considered feature of the aging process. Here we review the evidence that through reciprocal and multilevel functional interactions, mitochondria are implicated in the lifespan modulation function of these pathways, which altogether constitute a highly dynamic and complex system that controls the aging process. An important characteristic of these pathways is their extensive crosstalk and apparent malleability to modification by non-invasive pharmacological, dietary, and lifestyle interventions, with pr...

Mitochondria in the signaling pathways that control longevity and health span