D-optimal design of b-values for precise intra-voxel incoherent motion imaging

The aim of this paper is to optimally design the set ofb-values for diffusion weighted MRI with the aim of precise estimation of intra-voxel incoherent motion (IVIM) parameters (fperfusion fraction,Dsslow diffusion,Df fast diffusion) according to the model developed by Le Bihan. Previous studies have addressed the design in a Monte Carlo fashion; however, due to huge computation times, this approach is practical only for a limited number of...