Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
Abstract
Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated in diseases such as ischaemic organ damage and cancer1,2. The enzyme glutathione peroxidase 4 (GPX4) is a central regulator of ferroptosis, and protects cells by neutralizing lipid peroxides, which are by-products of cellular metabolism. The direct inhibition of GPX4, or indirect inhibition by depletion of its substrate...
Paper Details
Title
Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
Published Date
Jul 24, 2019
Journal
Volume
572
Issue
7769
Pages
402 - 406
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