Engineering

Bacteria

Biology

Materials science

Antibacterial activity

Biochemistry

Antibiotic resistance

Chalcone

Computational biology

Drug discovery

Stereochemistry

Biochemical engineering

Genetics

Combinatorial chemistry

Nanotechnology

Antibiotics

Pharmacology

Chemistry

Multiple drug resistance

Bioorganic Chemistry

The increase in antibiotic resistance due to various factors has encouraged the look for novel compounds which are active against multidrug-resistant pathogens. In this framework, chalcone-based compounds showed a diversity of pharmacological properties, and its derivatives possess a high degree of structural diversity, and it is helpful for the discovery of new therapeutic agents. The growing resistance to antibiotics worldwide has endangered their efficacy. This has led to a surging interest in the discovery of new antibacterial agents. Thus, there is an urgent need for new antibacterial drug candidates with increased strength, new targets, low cost, superior pharmacokinetic properties, and minimum side effects. The present review concluded and focuses on the recent developments in the area of medicinal chemistry to explore the diverse chemical structures of potent antibacterial agents and also describes its structure-activity relationships studies. The various synthetic structures leading to this class of neutral protective compound is common and additional structural optimization is promising for potential drug discovery and development.

Chalcone derivatives and their antibacterial activities: Current development