Original paper
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors
Volume: 129, Issue: 8, Pages: 3435 - 3447
Published: Jul 21, 2019
Abstract
Irreversible T cell exhaustion limits the efficacy of programmed cell death 1 (PD-1) blockade. We observed that dual CD40-TLR4 stimulation within a single tumor restored PD-1 sensitivity and that this regimen triggered a systemic tumor-specific CD8+ T cell response. This approach effectively treated established tumors in diverse syngeneic cancer models, and the systemic effect was dependent on the injected tumor, indicating that treated tumors...
Paper Details
Title
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors
Published Date
Jul 21, 2019
Volume
129
Issue
8
Pages
3435 - 3447