Simultaneous Determination of Four Monoamine Neurotransmitters and Seven Effective Components of Zaoren Anshen Prescription in Rat Tissue using UPLC-Ms/Ms

Background: Zaoren Anshen Prescription (ZAP) is widely used as a classic Chinese Traditional Medicine (TCM) prescription for the treatment of palpitations and insomnia in China. Some studies have identified the main active components for its anti-insomnia effect and observed changes of some endogenous components that are closely related to its anti-insomnia effect. However, simultaneous determination of four monoamine neurotransmitters and seven...