Internal medicine

Neuroscience

Disease

Neuromodulation

Central nervous system

Bioinformatics

Biology

Gene

Genetic enhancement

Psychology

Parkinson's disease

Deep brain stimulation

Clinical trial

Biochemistry

Medicine

Parkinsonism & Related Disorders

Gene therapy has been employed in the human brain for a number of disorders in clinical trials and may serve as an avenue for the treatment of Parkinson's disease (PD). Several gene therapy treatment strategies have been developed and evaluated in patients with PD. Three main strategies have been used-enhancement of dopamine synthesis, expression of trophic factors, and neuromodulation. Typically, genes are delivered via viral vectors and expressed within neurons in PD-relevant areas of the brain such as the striatum.

Human gene therapy approaches for the treatment of Parkinson's disease: An overview of current and completed clinical trials