Parkinsonism & Related Disorders
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#1Gina Ferrazzano (Sapienza University of Rome)H-Index: 11
#2Viviana Frantellizzi (Sapienza University of Rome)H-Index: 12
Last. Alfredo Berardelli (Sapienza University of Rome)H-Index: 97
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#2Fernando Rodríguez de Fonseca (UMA: University of Málaga)H-Index: 61
Last. Ana Santurtún (UC: University of Cantabria)H-Index: 11
view all 5 authors...
Abstract Background The enzyme ATP13A2 holds promise as biomarker in Parkinson`s disease (PD). No study has examined the content of ATP13A2 in serum and cerebrospinal fluid (CSF) in idiopathic PD cohorts, or how ATP13A2 relates to the clinical features of the disease. Methods ATP13A2 concentration was evaluated with ELISA and immunoblotting. Correlations of serum and CSF ATP13A2 with clinical parameters were examined. The antiparkinsonian medication regimen was expressed as levodopa equivalent d...
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#1Eoin Mulroy (UCL Institute of Neurology)H-Index: 4
#2Nirosen Vijiaratnam (UCL Institute of Neurology)H-Index: 7
Last. Patricia Limousin (UCL Institute of Neurology)H-Index: 88
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Abstract High frequency deep brain stimulation (DBS) of the internal portion of the globus pallidus has, in the last two decades, become a mainstream therapy for the management of medically-refractory dystonia syndromes. Such increasing uptake places an onus on movement disorder physicians to become familiar with this treatment modality, in particular optimal patient selection for the procedure and how to troubleshoot problems relating to sub-optimal efficacy and manage therapy-related side effe...
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#1Chi-Ying Roy Lin (CUMC: Columbia University Medical Center)
#2Nicole Rosendale (UCSF: University of California, San Francisco)H-Index: 6
Last. Wissam Deeb (UMass: University of Massachusetts Amherst)
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Culturally competent and inclusive care is slowly becoming the standard throughout healthcare institutions. Awareness, acceptance, and inclusion of the sexual and gender minority (SGM) groups in medicine and neurology are progressing. Research in SGM health, although increasing, remains remarkably scant in parkinsonism and other movement disorders, a community whose patient population is on the rise. Most SGM health research in movement disorders only focuses on the symptoms associated with infe...
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Abstract Background No study investigated the prevalence of pediatric Huntington's Disease. Methods Prevalence was analyzed in ENROLL-HD from participants and family trees. Results 50 compared with 7544 adult (0.66%) and 22 out of 16,124 family participants (0.14%) were pediatric. Conclusions The pediatric prevalence in the biggest HD study ranges unexpected low between 0.14 and 0.66%.
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#1Margherita Fabbri (University of Toulouse)H-Index: 9
#2Federico Natale (UNITO: University of Turin)
Last. Maurizio Zibetti (UNITO: University of Turin)H-Index: 32
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Abstract Background subthalamic nucleus deep brain stimulation (STN-DBS) may have a detrimental effect on speech in Parkinson’s disease (PD) patients and new stimulation technologies may help in addressing this issue. Objective to evaluate the STN-DBS acute effect of 30 μs pulse width (30PW) versus conventional 60 μs PW (60PW) on speech and identify the core features of voice modified by 30PW. Methods seven STN-DBS treated PD patients participated into a pilot cross-sectional study. Motor and sp...
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#1Philippe A. Salles (Cleveland Clinic)H-Index: 1
#2Ignacio F. Mata (Cleveland Clinic)H-Index: 31
Last. Hubert H. Fernandez (Cleveland Clinic)H-Index: 76
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Abstract Parkinson disease (PD) is a complex heterogeneous neurodegenerative disorder. Association studies have revealed numerous genetic risk loci and variants, and about 5-10% suffer from a monogenic form. Because the presentation and course of PD is unique to each patient, personalized symptomatic treatment should ideally be offered to treat the most disabling motor and non-motor symptoms. Indeed, clinical milestones and treatment complications that appear during disease progression are influ...
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#1Takashi AsahiH-Index: 9
#2Kiyonobu IkedaH-Index: 14
Last. Shuji SatoH-Index: 3
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Abstract We report two cases of granuloma that occurred around an implantable pulse generator (IPG) for deep brain stimulation. Both cases showed no signs of infection and disappeared after moving the IPG and removing the granulation. If a noninfectious mass is formed, the relocation of IPG may improve it.
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#1Jinhee Kim (KU: Korea University)H-Index: 2
#2Ilsoo Kim (KU: Korea University)H-Index: 1
Last. Seong-Beom Koh (KU: Korea University)H-Index: 10
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Abstract We report a novel variant of DHDDS mutation in a patient with progressive adult-onset myoclonus ataxia. The mutation in our patient was different from previous reports of denovo mutations in DHDDS in 6 patients who showed tremor-like myoclonus and generalized epilepsy.
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#1Jakub Surkont (U of A: University of Alberta)
#2Stephen Joza (U of A: University of Alberta)H-Index: 2
Last. Fang Ba (U of A: University of Alberta)H-Index: 7
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Abstract BACKGROUND Gait impairments are common in Parkinson’s Disease (PD) and are likely caused by degeneration in multiple brain circuits, including the basal ganglia, thalamus and mesencephalic locomotion centers (MLC). Diffusion tensor imaging (DTI) assesses fractional anisotropy (FA) and mean diffusivity (MD) that reflect the integrity of neuronal microstructure. We hypothesized that DTI changes in motor circuits correlate with gait changes in PD. OBJECTIVE We aimed to identify microstruct...
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