Metabolic Systems Analysis of Shock-Induced Endotheliopathy (SHINE) in Trauma

Objective: Investigate the endothelial cell phenotype (s) that causes Shock-Induced Endotheliopathy in trauma. Background: We have studied more than 2750 trauma patients and identified that patients with high circulating syndecan-1 (endothelial glycocalyx damage marker) in plasma have an increased mortality rate compared with patients with lower levels. Notably, we found that patients suffering from the same trauma severity could develop...