Original paper
A new pragmatic design for dose escalation in phase 1 clinical trials using an adaptive continual reassessment method
Abstract
A key challenge in phase I trials is maintaining rapid escalation in order to avoid exposing too many patients to sub-therapeutic doses, while preserving safety by limiting the frequency of toxic events. Traditional rule-based designs require temporarily stopping recruitment whilst waiting to see whether enrolled patients develop toxicity. This can be both inefficient and introduces logistic challenges to recruitment in the clinic. We describe a...
Paper Details
Title
A new pragmatic design for dose escalation in phase 1 clinical trials using an adaptive continual reassessment method
Published Date
Jun 26, 2019
Journal
Volume
19
Issue
1
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Notes
History