Original paper
Abstract 3496: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Abstract
Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (n= 16/26) in brain tumors developing in mice deficient for factors involved in homologous recombination repair or non-homologous end-joining. Catastrophic events were tightly linked to Myc/Mycn amplification, with increased DNA damage and inefficient apoptotic...
Paper Details
Title
Abstract 3496: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Published Date
Jul 1, 2019
Journal
Volume
79
Issue
13_Supplement
Pages
3496 - 3496
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Notes
History