HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

Volume: 75, Issue: 4, Pages: 711 - 724.e5
Published: Aug 1, 2019
Abstract
The energetic costs of duplicating chromatin are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs. By studying chromatin modifiers regulated by epithelial growth factor, we identified histone acetyltransferase 1 (HAT1) as an induced gene that enhances proliferation through coordinating histone production, acetylation, and glucose metabolism. In addition to its canonical role as a cytoplasmic histone H4...
Paper Details
Title
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
Published Date
Aug 1, 2019
Volume
75
Issue
4
Pages
711 - 724.e5
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