Enteropathy

Stomach

Small intestine

Endoscopy

Internal medicine

Gastrointestinal tract

Odds ratio

Medicine

Gastroenterology

Duodenum

Disease

Capsule endoscopy

Abdominal pain

<h3>Background</h3> Non-steroidal anti-inflammatory drugs (NSAIDs) can damage all parts of the gastrointestinal tract (GIT). However, the frequency of the combination of lesions in different parts of the gastrointestinal tract has not been studied. <h3>Objectives</h3> To assess the frequency of the combination of NSAID-induced lesions of the upper GI tract, small and large intestine. <h3>Methods</h3> The study group consisted of 112 patients with rheumatic diseases (62.5% of women, 56.2 + 14.6 years), who regularly took NSAIDs. All patients underwent endoscopy of the upper GI tract and colon. Capsule endoscopy was performed in 35 patients with signs of NSAID-gastropathy. <h3>Results</h3> NSAID-gastropathy (erosions and/or gastric or duodenum ulcers) were detected in 43.8%, NSAID enteropathy (hemorrhages, erosions and ulcers of the small intestine) in 68.6%, NSAIDs-colopathy (hemorrhages, erosions and ulcers of the colon) - 14.3% patients. The combination of NSAID-gastro- and colonopathy was detected in 28.6% of patients (odds ratio 12.2, 95% CI 2.619-56.84), the combination of NSAID-gastro, entero- and colopathy - in 10 patients (20.4% of the number of patients with NSAID-gastropathy). There was a significant risk association for the development of NSAID-induced lesions in all parts of the GI tract with a diagnosis of spondyloarthritis, the presence of abdominal pain, small intestine bacterial overgrowth, as well as in the polymorphism of the CYP2C19 gene (CYP2C19 * 17 * 1/* 17 allele). <h3>Conclusion</h3> The combined NSAID-induced damage of various parts of the GI tract is a frequent and serious pathology requiring complex diagnostics and the combined use of prophylactic agents with a different mechanism of action. <h3>Disclosure of Interests</h3> None declared

AB0297 HOW OFTEN IS THE COMBINATION OF NSAID-INDUCED LESIONS OF THE UPPER AND LOWER GI TRACT?