Preferable background filtering for next-generation sequencing analysis in non-small cell lung cancer: pericarcinomatous tissues or peripheral blood lymphocytes?

Dear editor, Lung cancer is the leading cause of cancer-related death worldwide, with the predominant pathological type being non-small cell lung cancer (NSCLC) [1, 2]. Next-generation sequencing (NGS) analysis is increasingly used to help clinicians select appropriate target therapies, such as epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for EGFR-mutant patients [3]. Both pericarcinomatous tissues and peripheral blood...