Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview.

Published on Sep 1, 2019in Biomedicine & Pharmacotherapy4.545
· DOI :10.1016/J.BIOPHA.2019.109060
Lu-Lin Miao3
Estimated H-index: 3
(CDUTCM: Chengdu University of Traditional Chinese Medicine),
Qin-Mei Zhou11
Estimated H-index: 11
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
+ 2 AuthorsLiang Xiong15
Estimated H-index: 15
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
Abstract Leonurus japonicus Houtt. is a traditional medicinal herb with significant effects; dating back more than 1800 years, it is widely used in Asia. In traditional Chinese medicine, it is essential in the treatment of menstrual and delivery disorders caused by blood stasis, such as dysmenorrhea, amenorrhea, and postpartum hemorrhage. In the last three decades, many phytochemists, pharmacologists, and doctors have focused on the chemical components, pharmacological activities, and clinical applications of L. japonicus . More than 280 chemical compounds have been isolated from this plant. The effects of most of the terpenoids and alkaloids isolated from the plant have been found to be closely related to the traditional functions of L. japonicus . Owing to its excellent therapeutic effects for obstetrical and gynecological diseases, L. japonicus has been widely used in both ancient and modern times. Nowadays, it has also been developed into a series of Chinese patent medicines in clinics in China. This review summarizes the phytochemistry, pharmacology, and clinical applications of L. japonicus .
#1Hu Yumei (Nanjing University of Chinese Medicine)H-Index: 4
Last. Wei Xiao
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AbstractTwo new labdane diterpenoids, Leojaponin E (1) and F (2), together with three known compounds were isolated from the dried herb of Leonurus japonicus Houtt., Lamiaceae. Their structures were determined based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. In addition, compounds 1 and 2 exerted inhibition of LPS-induced PGE2 production in a dose-dependent manner a...
5 CitationsSource
#1Min-Hong Jiang (SYSU: Sun Yat-sen University)H-Index: 2
#2Yue Hu (SYSU: Sun Yat-sen University)H-Index: 2
Last. Dongmei Wang (SYSU: Sun Yat-sen University)H-Index: 21
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AbstractFive fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2–10) along with a seco-labdane (11) were isolated from the aerial parts of Leonurus japonicus. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound 4 (6β-hydroxy-15,16-epoxylabda-8...
3 CitationsSource
#1Habib Haybar (Ahvaz Jundishapur University of Medical Sciences)H-Index: 9
#2Saeid Shahrabi (Semnan University)H-Index: 13
Last. Najmaldin Saki (Ahvaz Jundishapur University of Medical Sciences)H-Index: 20
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#1Qin-Mei Zhou (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 11
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Abstract Three new triterpenoids (1, 4, and 5), together with 17 known analogues, were isolated from the ethyl acetate soluble portion of the EtOH extract of Leonurus japonicus Houtt. Their structures were determined by spectroscopic analysis. All known triterpenoids were isolated from the genus Leonurus for the first time. Among them, triterpenoids 2–3, 9–12, and 16–20 were first isolated from the family Lamiaceae. Furthermore, the cycloartane, taraxastane, ursane, lupane, euphane, and dammaran...
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#1Wenwen Peng (JXAU: Jiangxi Agricultural University)H-Index: 3
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Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3–5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.
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#1Kuan-Ying Lai (PRC: China Medical University (PRC))H-Index: 1
#2Hao-Chun Hu (KMU: Kaohsiung Medical University)H-Index: 1
Last. Chia Lin Lee (PRC: China Medical University (PRC))H-Index: 16
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Abstract Six new diterpenes, leojaponins G–L (1–6) along with 19 known compounds (7–25) were isolated from Leonurus japonicus. Their structures were elucidated by NMR, MS, IR, UV, and ECD spectroscopic data. Anti-melanogenesis assay indicated that 7 could safely and dose-dependently decrease melanin production in B16F10 melanoma cell with an IC50 value of 59.1 μM, but moderately inhibit tyrosinase activity. Without cytotoxicities at 20 μM, compounds 11, 14, 15, and 17–21 showed significant melan...
5 CitationsSource
#1Yu-Lin He (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 3
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Last. Liang Xiong (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 15
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Abstract There is growing evidence that motherwort ( Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to angiogenesis. To test this hypothesis, we investigated the angiogenic effects of motherwort total alkaloids and essential oil, as well as their respective primary components,...
15 CitationsSource
#1Yun Liu (NCU: Nanchang University)H-Index: 1
#2Songzhi Wei (NCU: Nanchang University)H-Index: 1
Last. Yan Luo (NCU: Nanchang University)H-Index: 1
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#1Ruihan Zhang (Yunnan University)H-Index: 10
#2Zhi‐Ke Liu (CAS: Chinese Academy of Sciences)H-Index: 3
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Plants belonging to the genus Leonurus, also named motherwort, are traditionally used for anti gynecological disorder in East Asia, and for sedative in Europe. Chemical investigation of the genus Leonurus not only enriched the natural products library, but also enlarged the pharmacological application of this traditional herb. In this review, we systematically summarized the structures of 259 compounds isolated from the genus Leonurus, featured with 147 labdane diterpenoids. The reported bioacti...
26 CitationsSource
#1Juan Liu (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 5
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Abstract The crude extract and some Chinese patented medicines of Leonurus japonicus Houtt. have been proven to affect the uterine smooth muscle. L. japonicus injection is widely used in obstetric departments in China for treating postpartum hemorrhage caused by uterine inertia. Bioassay-guided isolation of the 95% EtOH extract of L. japonicus yielded four cyclopeptides, nine alkaloids, and three flavonoid glycosides, including two previously undescribed cyclopeptides, namely, cycloleonuripeptid...
14 CitationsSource
Cited By15
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1. Leonurine hydrochloride (LH) is derived from an ingredient of Leonurus japonicus Houtt which is widely used for diseases in women.2. The influence of LH on the activity of cytochrome P450 (CYPs) enzymes was investigated in this study.3. The effect of LH on CYPs enzyme activities were studied using the enzyme-selective substrates phenacetin (1A2), coumarin (2A6), diclofenac (2C9), S-mephenytoin (2C19), paclitaxel (2C8), dextromethorphan (2D6), chlorzoxazone (2E1) and testosterone (3A4). The IC...
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Last. Ruihan Zhang (Yunnan University)H-Index: 10
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Abstract null null Ethnopharmacological relevance null Duan Teng Yimu decoction is a Chinese herbal medicine compound with proven therapeutic effects on inflammasome-related diseases, such as rheumatoid arthritis. This decoction consists of three Chinese herbal medicines, including Leonurus japonicus (L. japonicus), which promotes the blood circulation and exhibits detumescence activity, traditionally curing gynecologic and inflammasome diseases. null null null Aim of the study null To explore t...
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Muscle atrophy, characterized by a reduced number and size of myofibers, occurs due to immobilization, aging, and several chronic diseases. Leonurus japonicus, belonging to the Labiatae family, has been greatly used as a traditional medicine in Korea, China, and Japan. Previous studies have reported that L. japonicus has various physiological activities, such as anti-bacteria, anti-cancer, and liver protection. Leonurine, which is a major bioactive in L. japonicas, is known to possess biological...
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Ischemic diseases, such as ischemic heart diseases and ischemic stroke, are the leading cause of death worldwide. Angiogenic therapy is a wide-ranging approach to fighting ischemic diseases. However, compared with anti-angiogenesis therapy for tumors, less attention has been paid to therapeutic angiogenesis. Recently, Traditional Chinese medicine (TCM) has garnered increasing interest for its definite curative effect and low toxicity. A growing number of studies have reported that TCM formulas, ...
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Abstract: The calcineurin (CaN)/nuclear factor of activated T-cell (NFAT) signalling pathway plays an important role in pathological cardiac hypertrophy. Here, we investigated the potential effects of stachydrine hydrochloride, a bioactive constituent extracted from the Chinese herb Leonurus japonicus Houtt. (Yimucao), on pathological cardiac hypertrophy during chronic α1-adrenergic receptor (α1-AR) activation and the underlying mechanisms. First, by transcriptome analysis, we determined that pa...
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