MiR-539-5p negatively regulates migration of rMSCs induced by Bushen Huoxue decoction through targeting Wnt5a

Bone fractures are very common, and above 5% of the fractures are impaired, leading to nonunions and severe disablilities.The traditional Chinese medicine Bushen Huoxue decoction (BHD) has been used to treat fracture in China.Our previous report has found that BHD promotes migration of rat mesenchymal stem cells (rMSCs) by activating Wnt5a signaling pathway.However, whether and how miRNAs are involved in modulating rMSCs migration induced by BHD...