Review paper
Protein kinase R and its cellular regulators in cancer: An active player or a surveillant?
Abstract
Protein kinase R (PKR), originally known as an antiviral protein, senses various stresses as well as pathogen‐driven double‐stranded RNAs. Thereby activated PKR provokes diverse downstream events, including eIF2α phosphorylation and nuclear factor kappa‐light‐chain‐enhancer of activated B cells activation. Consequently, PKR induces apoptosis and inflammation, both of which are highly important in cancer as much as its original antiviral role....
Paper Details
Title
Protein kinase R and its cellular regulators in cancer: An active player or a surveillant?
Published Date
Jun 23, 2019
Volume
11
Issue
2